Fig. 1 · Structure
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Ethacridine
PARG Inhibitor
Ethacridine is a potent inhibitor of poly(ADP-ribose) glycohydrolase (PARG), which plays a crucial role in the regulation of cellular responses to DNA damage. This compound has been shown to induce apoptosis in thyroid cancer cells, while also promoting differentiation in thyroid follicular cells. Its applications in cancer research and studies on cellular signaling pathways make it a valuable tool for understanding tumor biology and therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 442-16-0 |
| Applications | PARG Inhibitor |
| Formula | C15H15N3O |
| Molecular Weight | 253.30 |
| SMILES | CCOC1=CC2=C(C3=CC=C(C=C3N=C2C=C1)N)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.