Fig. 1 · Structure

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ETP-45835

MNK Inhibitor

ETP-45835 is a selective and potent inhibitor of the MNK kinases, demonstrating IC50 values of 575 nM for MNK1 and 646 nM for MNK2. Its specificity is underscored by minimal activity against 24 other kinases. ETP-45835 effectively inhibits eIF4E phosphorylation at Ser209 in cellular models and exhibits anticancer activity, making it a valuable tool for research on cancer biology and signaling pathways involving MNK regulation.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 794510-70-6
Applications MNK Inhibitor
Formula C13H16N4
Molecular Weight 228.29
SMILES
N=1C=CC(=CC1)C2=NNC(=C2)C3CCNCC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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