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EU 1622-240

GluN2B/C/D Biased PAM

EU 1622-240 is a biased positive allosteric modulator targeting GluN2B, GluN2C, and GluN2D NMDA receptor subtypes, exhibiting EC50 values of 0.57, 0.82, and 1.1 μM, respectively. This compound demonstrates favorable physicochemical properties and maintains in vitro stability and permeability. EU 1622-240 holds potential for research applications in neuropharmacology and the study of synaptic transmission and plasticity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Modulator
CAS Number	3057728-22-7
Applications	GluN2B/C/D Biased PAM
Formula	C₂₀H₁₄BrF₂N₃O₂S
Molecular Weight	478.31
SMILES	C#CC1=C(C2=C(N=CN(C2=O)CC(N3CC(F)(C3)C)=O)S1)C4=CC=C(C(Br)=C4)F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.