Fig. 1 · Structure
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Evixapodlin
PD-1/PD-L1 PPI Inhibitor
Evixapodlin is a potent inhibitor of the PD-1/PD-L1 protein-protein interaction, exhibiting an IC50 of 0.213 nM. This compound demonstrates significant anticancer and antiviral activities, making it a valuable tool for research in immunotherapy and viral pathogenesis. Evixapodlin is particularly useful for studying the modulation of immune responses in tumor environments and understanding the interplay between immune checkpoints and viral infections.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2374856-75-2 |
| Applications | PD-1/PD-L1 PPI Inhibitor |
| Formula | C34H36Cl2N8O4 |
| Molecular Weight | 691.61 |
| Synonyms | GS-4224; PD-1/PD-L1-IN 7 |
| SMILES | ClC1=C(C(C=CC=C2C(C=N3)=NC(OC)=C3CNC[C@H](CC4)NC4=O)=C2Cl)C=CC=C1C(C=N5)=NC(OC)=C5CNC[C@H](CC6)NC6=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.