Fig. 1 · Structure
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EVT-101 free base
GluN2B Antagonist
EVT-101 free base is a selective antagonist of the GluN2B subunit of the NMDA receptor. It acts by binding at the GluN1/GluN2B dimer interface, effectively inhibiting calcium influx in neuronal cells, with an EC50 value of 22 nM. This compound is primarily utilized in research focusing on various neurological disorders and excitotoxicity pathways, making it a valuable tool for understanding GluN2B-related signaling mechanisms.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 627525-33-1 |
| Applications | GluN2B Antagonist |
| Formula | C16H13F3N4 |
| Molecular Weight | 318.30 |
| Synonyms | ENS-101 free base |
| SMILES | CC1=NC=CN1CC2=NN=CC(C3=CC=C(F)C(C(F)F)=C3)=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.