Fig. 1 · Structure
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Exaluren
Nonsense Mutation Read-through Inducer
Exaluren (ELX-02; NB-124) is a synthetic eukaryotic ribosome-selective glycoside that functions as a nonsense mutation read-through inducer. This compound enhances the translational process, enabling the production of full-length, functional proteins from mRNAs that contain premature stop codons. Exaluren is primarily utilized in research applications related to cystic fibrosis and other genetic disorders caused by nonsense mutations, offering potential insights into therapeutic avenues for these conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 1375073-93-0 |
| Applications | Nonsense Mutation Read-through Inducer |
| Formula | C19H38N4O10 |
| Molecular Weight | 482.53 |
| Synonyms | ELX-02; NB-124 |
| SMILES | C[C@@H](O)[C@@]([C@@H](O)[C@H](O)[C@H]1N)([H])O[C@]1([H])O[C@H]([C@H](C[C@@H](N)[C@@H]2O)N)[C@]2([H])O[C@@H]3O[C@@]([C@@H](N)C)([H])[C@@H](O)[C@H]3O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.