Fig. 1 · Structure
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Exatecan-amide-bicyclo1.1.1pentan-1-ol
Exatecan Derivatives
Exatecan-amide-bicyclo[1.1.1]pentan-1-ol is a derivative of exatecan that serves as a potent payload in targeted drug conjugates. This compound demonstrates significant cytotoxic activity against various tumor cell lines, making it a valuable tool in cancer research. Its mechanistic properties facilitate investigations into the efficacy of novel therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2866299-06-9 |
| Applications | Exatecan Derivatives |
| Formula | C30H28FN3O6 |
| Molecular Weight | 545.56 |
| SMILES | O=C(C12CC(C1)(C2)O)N[C@@H]3C4=C5C(C(N6C5)=CC([C@](O)(C(OC7)=O)CC)=C7C6=O)=NC8=CC(F)=C(C)C(CC3)=C84 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.