Fig. 1 · Structure
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Exatecan-amide-bicyclo1.1.1pentan-1-ylmethanol
Camptothecin Compound
Exatecan-amide-bicyclo[1.1.1]pentan-1-ylmethanol is a camptothecin derivative that targets topoisomerase I, leading to the inhibition of cell proliferation. It demonstrates potent anticancer activity with an IC50 value of 2.92 ng/mL in MDA-MB-468 breast cancer cells. This compound is suitable for research applications focusing on cancer biology and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2891774-71-1 |
| Applications | Camptothecin Compound |
| Formula | C31H30FN3O6 |
| Molecular Weight | 559.58 |
| SMILES | O=C1N2C(C3=NC4=CC(F)=C(C)C(CC5)=C4C([C@H]5NC(C67CC(C6)(C7)CO)=O)=C3C2)=CC([C@](O)8CC)=C1COC8=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.