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Exatecan analog 13

Exatecan Analog

Exatecan analog 13 is a derivative of Exatecan, a well-characterized DNA topoisomerase I inhibitor with an IC50 of 2.2 μM. This compound serves as a cytotoxic agent in antibody-drug conjugate (ADC) formulations, enhancing targeted delivery and efficacy in cancer therapy. Its ability to interfere with DNA replication makes it a valuable tool for studying topoisomerase-mediated processes and developing novel chemotherapeutic strategies.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1599439-47-0
Applications	Exatecan Analog
Formula	C₂₈H₂₉FN₄O₅
Molecular Weight	520.55
SMILES	NCCCC(N[C@@H]1C2=C3C(C(N4C3)=CC([C@](O)(C(OC5)=O)CC)=C5C4=O)=NC6=CC(F)=C(C)C(CC1)=C62)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.