Fig. 1 · Structure
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Exatecan intermediate 12
Intermediate
Exatecan intermediate 12 is a key intermediate in the synthesis of the antibody-drug conjugate (ADC) toxin Exatecan. This compound plays a crucial role in the preparation of ADCs, facilitating the attachment of cytotoxic agents to antibodies for targeted cancer therapy. Its utility in research includes the development of novel ADC formulations aimed at enhancing therapeutic efficacy and reducing systemic toxicity in oncological applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 110351-93-4 |
| Applications | Intermediate |
| Formula | C15H17NO6 |
| Molecular Weight | 307.30 |
| SMILES | O=C1N2C(C3(OCCO3)CC2)=CC4=C1COC([C@]4(O)CC)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.