Fig. 1 · Structure
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Exatecan Intermediate 5
Exatecan Intermediate
Exatecan Intermediate 5 is a key precursor in the synthesis of Exatecan, a DNA topoisomerase I inhibitor with an IC50 of 2.2 μM. This compound demonstrates significant potential in cancer research by disrupting DNA replication in cancer cells. Additionally, Exatecan Intermediate 5 serves as a vital building block for the development of antibody-drug conjugates (ADCs), enabling targeted therapeutic strategies in oncology.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 143655-70-3 |
| Applications | Exatecan Intermediate |
| Formula | C15H17FN2O3 |
| Molecular Weight | 292.31 |
| SMILES | FC1=CC(NC(C)=O)=C(C(C(NC(C)=O)CC2)=O)C2=C1C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.