Fig. 1 · Structure
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Exatecan intermediate 9
Intermediate
Exatecan intermediate 9 serves as a crucial synthetic precursor in the production of Exatecan, also known as DX-8951. This compound acts primarily as an inhibitor of DNA topoisomerase I, exhibiting biological activity with an IC50 of 2.2 μM. It plays a significant role in the development of antibody-drug conjugates (ADCs), particularly in the formulation of cytotoxic agents for targeted cancer therapies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2290562-59-1 |
| Applications | Intermediate |
| Formula | C26H24FN3O5 |
| Molecular Weight | 477.48 |
| SMILES | O=C(OC1)[C@](O)(CC)C2=C1C(N3C(C4=NC5=CC(F)=C(C)C6=C5C(C(NC(C)=O)CC6)=C4C3)=C2)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.