Fig. 1 · Structure
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EZ-482
ApoE Ligand
EZ-482 is a novel ligand specifically targeting apolipoprotein E (apoE), exhibiting binding affinities (Kd) of 5-10 μM for both apoE3 and apoE4 isoforms. This compound engages apoE4 through a distinct N-terminal allosteric mechanism. EZ-482 demonstrates potential applications in Alzheimer's disease research, making it a valuable tool for studies focused on apoE-related pathways and their implications in neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 1016456-76-0 |
| Applications | ApoE Ligand |
| Formula | C23H19ClN4O5S |
| Molecular Weight | 498.94 |
| SMILES | O=C(NC1=CC(S(=O)(NC2=CC=CC(Cl)=C2)=O)=CC=C1O)CC3=NN(C)C(C4=C3C=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.