Fig. 1 · Structure
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Fabesetron (FK1052 free base)
5-HT3/5-HT4 Receptor Antagonist
Fabesetron is an orally active antagonist of both the 5-HT3 and 5-HT4 receptors. It exhibits significant biological activity in mitigating both acute and delayed emesis associated with cancer chemotherapy. This compound is valuable for research applications focusing on antiemetic therapies and the modulation of serotonin receptors in gastrointestinal motility.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 129300-27-2 |
| Applications | 5-HT3/5-HT4 Receptor Antagonist |
| Formula | C18H19N3O |
| Molecular Weight | 293.36 |
| Synonyms | FK1052 free base |
| SMILES | O=C1N2C3=C(C=CC=C3)C(C)=C2CC[C@@H]1CC4=C(NC=N4)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.