Fig. 1 · Structure
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Factor D inhibitor 6
Factor D Inhibitor
Factor D Inhibitor 6 is a selective inhibitor of Factor D, exhibiting a potent inhibitory activity with an IC50 of 30 nM and a Kd of 6 nM. It demonstrates high specificity, being inactive against Factor B and not affecting classical or lectin complement pathway activation, as well as a range of receptors, ion channels, kinases, and proteases. This compound is useful in research involving the complement system and its associated pathways, providing significant potential for therapeutic application in diseases influenced by aberrant complement activation.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1386455-51-1 |
| Applications | Factor D Inhibitor |
| Formula | C23H22ClFN6O3 |
| Molecular Weight | 484.91 |
| SMILES | O=C([C@H]1N(C(CN2N=C(C(N)=O)C3=C2C=NC=C3)=O)[C@]4([H])C[C@]4([H])C1)N[C@@H](C5=CC=CC(Cl)=C5F)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.