Fig. 1 · Structure
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Fadrozole hydrochloride hemihydrate
Aromatase Inhibitor
Fadrozole hydrochloride hemihydrate is a selective nonsteroidal aromatase inhibitor that effectively reduces estrogen and progesterone synthesis, exhibiting IC50 values of 0.03 μM and 120 μM respectively. With an IC50 of 6.4 nM, it demonstrates potent activity against aromatase, making it valuable for investigating estrogen-dependent diseases. This compound is useful in cancer research, particularly for studying tumor prevention and the modulation of hormone-related pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 176702-70-8 |
| Applications | Aromatase Inhibitor |
| Formula | C14H13N3.ClH.1/2H2O |
| Molecular Weight | 268.74 |
| Synonyms | CGS 16949A hemihydrate; (Rac)-FAD286 hydrochloride hemihydrate |
| SMILES | N#CC1=CC=C(C=C1)C2CCCC3=CN=CN23.[H]Cl.[H]O[H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.