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Fig. 1 · Structure
Cat. No.
A14106
CAS No.
801283-95-4
Formula
C40H49BrN6O9S
Mol. Weight
869.82

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Faldaprevir

Cat. No. A14106 CAS 801283-95-4

HCV Protease Inhibitor

Faldaprevir is a hepatitis C virus protease inhibitor.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
Huh-7 EC50 3.1 nM Antiviral activity against HCV 1b infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR [PMID: 20823284]
Huh-7 CC50 30000 nM Cytotoxicity activity against human HuH7 cells by MTT assay [PMID: 20823284]
Huh-7 EC50 43 nM Antiviral activity against HCV 2a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR [PMID: 20823284]
Huh-7 EC50 50 nM Antiviral activity against HCV 2a clone JFH1 infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR [PMID: 20823284]
Huh-7 EC50 6.5 nM Antiviral activity against HCV 1a infected in Huh7 cells assessed as inhibition of viral replication after 72 hrs by RT-PCR [PMID: 20823284]
Huh-7 EC50 6.5 nM Antiviral activity against Hepatitis C virus genotype 1b infected in human HuH7 cells by subgenomic replicon-based luciferase assay [PMID: 24900813]

Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 801283-95-4
Applications HCV Protease Inhibitor
Formula C40H49BrN6O9S
Molecular Weight 869.82
Synonyms BI201335
SMILES
CC(C)C(=O)NC1=NC(=CS1)C2=NC3=C(C=CC(=C3Br)OC)C(=C2)O[C@@H]4C[C@H](N(C4)C(=O)[C@H](C(C)(C)C)NC(=O)OC5CCCC5)C(=O)N[C@]6(C[C@@H]6C=C)C(=O)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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