Fig. 1 · Structure
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Fananserin
5-HT2 Receptor Antagonist
Fananserin is a potent and selective antagonist of the 5-hydroxytryptamine 2 (5-HT2) receptor, exhibiting a Ki value of 0.37 nM for the rat 5-HT2A receptor. Additionally, Fananserin serves as a selective antagonist for the dopamine D4 receptor, with a Ki of 2.93 nM for the human variant. This compound is valuable for research exploring the modulation of serotonin and dopamine pathways, offering insights into potential therapeutic applications in neuropsychiatric disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 127625-29-0 |
| Applications | 5-HT2 Receptor Antagonist |
| Formula | C23H24FN3O2S |
| Molecular Weight | 425.52 |
| Synonyms | RP 62203 |
| SMILES | FC1=CC=C(N2CCN(CCCN(C3=CC=CC4=C3C5=CC=C4)S5(=O)=O)CC2)C=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.