Fig. 1 · Structure
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Farabursen sodium
miR-17 Inhibitor
Farabursen sodium is a selective inhibitor of the microRNA-17 family. By effectively inhibiting the functionality of miR-17, it enhances the expression of target genes such as PKD1 and PKD2, leading to increased levels of polycystin-1 and -2 (PC1/2). This compound demonstrates significant potential in attenuating the growth of renal cysts and reducing kidney weight-to-body weight ratios, making it valuable for research into autosomal dominant polycystic kidney disease.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2921918-19-4 |
| Applications | miR-17 Inhibitor |
| Formula | C95H107F3N32Na8O50P8S8 |
| Molecular Weight | 3066.4 (free acid) |
| Synonyms | RGLS8429 sodium; RG1015 sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.