Fig. 1 · Structure
Documents & Downloads
Farabursen
miR-17 Inhibitor
Farabursen is a selective inhibitor of miR-17, designed to penetrate the blood-brain barrier. This compound effectively derepresses the target genes Pkd1 and Pkd2, leading to enhanced levels of polycystin-1 (PC1) and polycystin-2 (PC2), while simultaneously reducing cyst growth. In preclinical mouse models, Farabursen has been demonstrated to decrease renal cyst growth, lower kidney weight-to-body weight ratio, reduce cyst and proliferation indices, and decrease blood urea nitrogen levels. This reagent is valuable for research focused on autosomal dominant polycystic kidney disease.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2953012-32-1 |
| Applications | miR-17 Inhibitor |
| Synonyms | RGLS8429; RG1015 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.