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Faridoxorubicin

Prodrug

Faridoxorubicin (AVA-6000) is a prodrug that specifically targets fibroblast activation protein α (FAPα). Upon FAPα-mediated cleavage, it releases the active compound doxorubicin, which increases drug exposure within tumors while minimizing cardiac toxicity. This compound holds significant promise for research applications related to solid tumors, particularly in the context of colorectal cancer liver metastasis.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1841402-73-0
Applications	Prodrug
Formula	C₄₁H₄₄N₄O₁₄
Molecular Weight	816.81
Synonyms	AVA-6000
SMILES	OC1=C(C(C2=CC=CC(OC)=C2C3=O)=O)C3=C(O)C4=C1C[C@](C(CO)=O)(O)C[C@@H]4O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)NC([C@H]6N(CCC6)C([C@@H](C)NC(C7=CC=NC=C7)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.