Fig. 1 · Structure
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Fasentin
GLUT-1/GLUT-4 Inhibitor
Fasentin is a selective inhibitor of glucose transporters GLUT-1 and GLUT-4, with a particularly potent effect on GLUT-4 (IC50 = 68 μM). This compound functions as a sensitizer for death receptor signaling, enhancing the susceptibility of cells to Fas-induced apoptosis and TNF-related apoptosis-inducing ligand. Fasentin effectively inhibits glucose uptake in various cancer cell lines and exhibits anti-angiogenic activity, making it a valuable tool for research in cancer metabolism and therapeutic strategies targeting glucose transport.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 392721-37-8 |
| Applications | GLUT-1/GLUT-4 Inhibitor |
| Formula | C11H9ClF3NO2 |
| Molecular Weight | 279.64 |
| SMILES | CC(CC(NC1=CC=C(Cl)C(C(F)(F)F)=C1)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.