Fig. 1 · Structure
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FAUC 365
D3 Receptor Antagonist
FAUC 365 is a highly selective antagonist for the dopamine D3 receptor, exhibiting a Ki value of 0.5 nM. It demonstrates significantly lower binding affinities at D4.4, D2short, and D2Long receptors, with Ki values of 340 nM, 2600 nM, and 3600 nM, respectively. FAUC 365 is primarily utilized in research related to schizophrenia and Parkinson's disease, providing valuable insights into dopamine receptor interactions and potential therapeutic interventions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 474432-66-1 |
| Applications | D3 Receptor Antagonist |
| Formula | C23H25Cl2N3OS |
| Molecular Weight | 462.44 |
| SMILES | ClC1=C(C(N2CCN(CC2)CCCCNC(C3=CC4=C(S3)C=CC=C4)=O)=CC=C1)Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.