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FAZ-3532

G3BP Inhibitor

FAZ-3532 is a selective G3BP inhibitor that targets the NTF2L nsP3 binding pocket in G3BP1 with a Kd of 0.54 μM. This compound disrupts the co-condensation of RNA, G3BP1, and caprin 1, effectively inhibiting G3BP-driven stress granule formation. FAZ-3532 serves as a valuable tool for investigating the biological role of stress granules and offers potential for therapeutic strategies aimed at modulating stress granule dynamics.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	3036029-72-5
Applications	G3BP Inhibitor
Formula	C₃₈H₅₆FN₅O₇
Molecular Weight	713.88
SMILES	C[C@H]([C@H](NC([C@H](C(C)(C)O)NC([C@H](CC(C)(C)C)F)=O)=O)C(N[C@H](C)C(N[C@@H](CCOC)C(N(C)CC1=CC=CC=C1)=O)=O)=O)C2=CC=CC=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.