Fig. 1 · Structure
Documents & Downloads
Fazamorexant
Orexin Receptor Antagonist
Fazamorexant is a dual orexin receptor antagonist targeting both OX1R and OX2R, with IC50 values of 32 nM and 41 nM, respectively. This compound is known to enhance total sleep time and improve sleep efficiency, making it a valuable tool for the study of insomnia and sleep disorders. Fazamorexant is suitable for use in various research applications focused on therapeutic strategies for sleep-related conditions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 1808918-69-5 |
| Applications | Orexin Receptor Antagonist |
| Formula | C25H25FN4O2 |
| Molecular Weight | 432.49 |
| Synonyms | YZJ-1139 |
| SMILES | O=C(C1=C(C2=NC=CC=N2)C=CC(C)=C1)N3[C@]4([H])[C@@H](CC[C@@]3([H])CC4)COC5=CC=C(C=N5)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.