Fig. 1 · Structure
Documents & Downloads
Fazirsiran sodium
RNAi
Fazirsiran sodium is a second-generation RNA interference (RNAi) agent that targets Alpha-1 antitrypsin (AAT) mRNA. It comprises a cholesterol-conjugated RNAi trigger (chol-RNAi) designed for specific degradation of AAT mRNA, along with an endosomal escape-enhancing peptide derived from melittin, conjugated to N-acetylgalactosamine (NAG). This formulation facilitates effective delivery in hepatocytes. Fazirsiran sodium is primarily utilized in research related to Alpha-1 Antitrypsin Deficiency (AATD), a condition resulting from mutations in the SERPINA1 gene, which leads to liver disease.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2175009-09-1 |
| Applications | RNAi |
| Formula | C493H610F11N163Na43O312P43S6 |
| Molecular Weight | 15587.6 (free acid) |
| Synonyms | ARO-AAT sodium |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.