Fig. 1 · Structure
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FB231
Parkin Activator
FB231 is a Parkin activator that induces mild mitochondrial stress, leading to impaired mitochondrial function and the activation of the integrated stress response (ISR). This compound lowers the threshold for mitochondrial toxins to trigger PINK1/Parkin-mediated mitophagy and influences iron-dependent pathways. FB231 is valuable for research into neurological diseases, particularly Parkinson's disease, by providing insights into mitochondrial dysfunction and cellular stress responses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 2166045-37-8 |
| Applications | Parkin Activator |
| Formula | C24H21N5O2 |
| Molecular Weight | 411.46 |
| SMILES | CC1=C(C=CC=C1)C(NC2=NN(C(NC(C3=C(C=CC=C3)C)=O)=N2)C4=CC=CC=C4)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.