Fig. 1 · Structure
Documents & Downloads
FdUMP triethylammonium
Intracellular Active Form of 5-FU
FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU) and serves as a potent inhibitor of thymidylate synthase. Once inside the cell, 5-FU is converted to FdUMP, which subsequently forms a ternary complex with thymidylate synthase and its cofactor, 5,10-methylene tetrahydrofolate. This interaction effectively inhibits thymidylate synthase activity, leading to a decrease in DNA synthesis. FdUMP triethylammonium is commonly utilized in cancer research and therapeutic studies involving antifolate mechanisms.
In Stock
Free Aliquoting for Your Order
Tell us your preferred amount per vial. We’ll confirm the options.
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 134-46-3 |
| Applications | Intracellular Active Form of 5-FU |
| Formula | C21H42FN4O8P |
| Molecular Weight | 528.55 |
| Synonyms | 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium |
| SMILES | O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.