Fig. 1 · Structure
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FDW028
FUT8 Inhibitor
FDW028 is a potent and selective inhibitor of FUT8, a glycosyltransferase implicated in cancer progression. By inducing the defucosylation of glycoproteins, FDW028 promotes the lysosomal degradation of B7-H3 via the chaperone-mediated autophagy (CMA) pathway, demonstrating significant anti-tumor activity. This compound is primarily used in research related to metastatic colorectal cancer (mCRC), providing a valuable tool for investigating therapeutic strategies targeting FUT8.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 2768426-49-7 |
| Applications | FUT8 Inhibitor |
| Formula | C22H24N6O |
| Molecular Weight | 388.47 |
| SMILES | OC1=CC(CNCC2=CC=CC=C2)=NC3=NC(NCC4=CC=C(CC)C=C4)=NN31 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.