Fig. 1 · Structure
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Fenobam hydrate
mGluR5 Antagonist
Fenobam hydrate is a selective mGluR5 antagonist with an IC50 of 84 nM, capable of crossing the blood-brain barrier. It exhibits Kd values of 54 nM and 31 nM for rat and human recombinant mGlu5 receptors, respectively. Fenobam hydrate demonstrates anxiolytic properties, inhibits self-administration behavior in rodent models, and induces apoptosis in cancer cells. This compound is valuable for research in neurological disorders, cancer biology, and addiction studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 63540-28-3 |
| Applications | mGluR5 Antagonist |
| Formula | C11H13ClN4O3 |
| Molecular Weight | 284.70 |
| SMILES | O=C(NC1=NC(CN1C)=O)NC2=CC=CC(Cl)=C2.O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.