Fig. 1 · Structure
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Ferumoxytol
Iron Oxide Nanoparticles
Ferumoxytol is an iron oxide nanoparticle that targets iron metabolism pathways, exhibiting significant anti-leukemic activity, particularly against acute myeloid leukemia (AML) cells with low levels of the iron transporter protein (FPN). By enhancing intracellular iron accumulation, Ferumoxytol initiates the Fenton reaction, leading to the production of reactive oxygen species (ROS), resulting in oxidative stress and ferroptosis in cancer cells. This compound is instrumental for research into leukemia characterized by targeted iron metabolism alterations, providing a selective approach to eradicate leukemic cells while minimizing collateral damage to normal cells.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 722492-56-0 |
| Applications | Iron Oxide Nanoparticles |
| Formula | Fe3O4 |
| Molecular Weight | 231.53 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.