FHD-909

Catalog No.: A57050
SMARCA2 Inhibitor
FHD-909 is a selective inhibitor of SMARCA2 (BRM), exhibiting IC50 values of 2.5 nM for SMARCA2 and 123.7 nM for SMARCA4. This compound serves as a valuable tool for the investigation of BAF complex-related disorders, including various cancer types. Researchers can leverage FHD-909 to elucidate the role of SMARCA2 in oncogenesis and other pathological conditions associated with chromatin remodeling.
Grouped product items
Size Stock
5mg
10mg
50mg
Bulk Size
Bulk Discount
Free Delivery on orders over $500
Research use only. We do not sell to patients.

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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFHD-909 is a selective inhibitor of SMARCA2 (BRM), exhibiting IC50 values of 2.5 nM for SMARCA2 and 123.7 nM for SMARCA4. This compound serves as a valuable tool for the investigation of BAF complex-related disorders, including various cancer types. Researchers can leverage FHD-909 to elucidate the role of SMARCA2 in oncogenesis and other pathological conditions associated with chromatin remodeling.
Product Information
Catalog NumA57050
FormulaC29H25F2N5O5S
Molecular Weight593.60
CAS Number3008577-34-9
SMILESO=C(C1=CC(F)=C(OCC[C@@H](S2(=O)=O)F)C2=C1)NCC3=CC4=C(C=N3)C=CC(N5C6=NC(C7CC7)=CC=C6OCC5)=N4
SynonymsLY4050784
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