Fig. 1 · Structure
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FHND5032
MiR-124 Inducer
FHND5032 is an orally active miR-124 inducer that enhances miR-124 expression in macrophages. Its mechanism involves the inhibition of the PIK3R2/PI3K/Akt signaling pathway, leading to disrupted inflammatory signaling and improved macrophage reprogramming. FHND5032 has demonstrated efficacy in alleviating colitis and reducing the inflammatory burden in models of ulcerative colitis, making it a valuable reagent for research focused on inflammatory bowel diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 3076057-63-8 |
| Applications | MiR-124 Inducer |
| Formula | C15H9ClF3N3O |
| Molecular Weight | 339.70 |
| SMILES | FC(F)(OC1=CC=C(C=C1)NC2=NC3=CC(Cl)=CC=C3C=N2)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.