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Fibrinogen γ-chain (117-133)

ICAM-1 Inhibitor

Fibrinogen γ-chain (117-133) is a selective inhibitor of intercellular adhesion molecule-1 (ICAM-1), exhibiting an IC50 of approximately 20-40 μg/mL. This peptide effectively obstructs fibrinogen-mediated adhesion between monocytes and endothelial cells. It is a valuable tool for investigating thrombo-inflammatory conditions such as atherosclerosis and organ transplant rejection, providing insights into the mechanisms underlying these diseases.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	160927-63-9
Applications	ICAM-1 Inhibitor
Formula	C₈₄H₁₄₇N₂₅O₂₇
Molecular Weight	1939.22
SMILES	[C@@H](NC([C@@H](NC([C@@H](NC([C@H](CC(N)=O)N)=O)CC(N)=O)=O)CCC(N)=O)=O)(C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(O)=O)C)=O)CCC(O)=O)=O)CC(C)C)=O)CCC(N)=O)=O)C)=O)C(C)C)=O)CCCCN)=O)CCC(O)=O)=O)CCCCN)=O)CC(C)C)=O)CC(N)=O)=O)C(C)C)=O)[C@H](CC)C)=O)CCCCN

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.