Fig. 1 · Structure
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Fiduxosin hydrochloride
α1-Adrenoceptor Antagonist
Fiduxosin hydrochloride is a potent antagonist of the α1-adrenoceptor, exhibiting inhibitory constants (Ki) of 0.160 nM, 24.9 nM, and 0.920 nM for the α1A, α1B, and α1D subtypes, respectively. This compound demonstrates significant biological activity in modulating adrenergic signaling pathways. Its mechanism of action makes it a valuable tool for research in cardiovascular and urological studies, facilitating investigations into conditions such as hypertension and benign prostatic hyperplasia.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Antagonist |
| CAS Number | 208992-74-9 |
| Applications | α1-Adrenoceptor Antagonist |
| Formula | C30H30ClN5O4S |
| Molecular Weight | 592.11 |
| Synonyms | ABT 980 |
| SMILES | O=C1C2=C(NC(N1CCCCN3C[C@]4([H])[C@](COC5=CC=CC(OC)=C54)([H])C3)=O)C6=NC(C7=CC=CC=C7)=CN=C6S2.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.