Fig. 1 · Structure
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Filgotinib-d4
Stable Isotope
Filgotinib-d4 is a deuterated form of Filgotinib, a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 10 nM. This isotope-labeled compound retains Filgotinib's high selectivity, demonstrating IC50 values of 28 nM for JAK2, 810 nM for JAK3, and 116 nM for TYK2. Filgotinib-d4 is primarily used in pharmacokinetic studies and isotopic labeling research, facilitating investigations into JAK1-related pathways and therapeutic applications in autoimmune diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2041095-50-3 |
| Applications | Stable Isotope |
| Formula | C21H19D4N5O3S |
| Molecular Weight | 429.53 |
| Synonyms | GLPG0634-d4 |
| SMILES | O=C(C1C([2H])([2H])C1([2H])[2H])NC2=NN3C(C4=CC=C(C=C4)CN5CCS(=O)(CC5)=O)=CC=CC3=N2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.