Filgotinib-d4 is a deuterated form of Filgotinib, a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 10 nM. This isotope-labeled compound retains Filgotinib's high selectivity, demonstrating IC50 values of 28 nM for JAK2, 810 nM for JAK3, and 116 nM for TYK2. Filgotinib-d4 is primarily used in pharmacokinetic studies and isotopic labeling research, facilitating investigations into JAK1-related pathways and therapeutic applications in autoimmune diseases.
Filgotinib-d4 is a deuterated form of Filgotinib, a selective inhibitor of Janus kinase 1 (JAK1) with an IC50 of 10 nM. This isotope-labeled compound retains Filgotinib's high selectivity, demonstrating IC50 values of 28 nM for JAK2, 810 nM for JAK3, and 116 nM for TYK2. Filgotinib-d4 is primarily used in pharmacokinetic studies and isotopic labeling research, facilitating investigations into JAK1-related pathways and therapeutic applications in autoimmune diseases.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
