Fig. 1 · Structure
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Fitusiran
siRNA Approach Targeting AT Messenger RNA
Fitusiran is a small interfering RNA (siRNA) reagent that specifically targets the SERPINC1 gene in hepatocytes, effectively inhibiting the synthesis of antithrombin. By doing so, Fitusiran promotes enhanced thrombin activity and improves thrombin generation, which may restore normal hemostatic function. This compound is primarily utilized in research focused on hemophilia and related coagulopathy studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1499251-18-1 |
| Applications | siRNA Approach Targeting AT Messenger RNA |
| Molecular Weight | 16248.2 (AS: 7675 + SS: 8573.2) |
| Synonyms | ALN-AT3SC; SAR439774 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.