Fig. 1 · Structure
Documents & Downloads
FK706
Elastase Inhibitor
FK706 is a potent competitive inhibitor of human neutrophil elastase, exhibiting an IC50 of 83 nM and a Ki of 4.2 nM. This compound effectively inhibits both mouse neutrophil elastase and porcine pancreatic elastase, with IC50 values of 22 nM and 100 nM, respectively. Importantly, FK706 shows selectivity by not inhibiting other serine proteinases, including human pancreatic trypsin and α-chymotrypsin. Due to its anti-inflammatory properties, FK706 is valuable for research related to inflammatory diseases and conditions associated with elastase activity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 144055-55-0 |
| Applications | Elastase Inhibitor |
| Formula | C26H32F3N4NaO7 |
| Molecular Weight | 592.54 |
| SMILES | O=C(NC(C(C)C)C(C(F)(F)F)=O)[C@H]1N(C([C@H](C(C)C)NC(C2=CC=C(C(NCC(O[Na])=O)=O)C=C2)=O)=O)CCC1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.