Fig. 1 · Structure
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FKGK18
GVIA iPLA2 Inhibitor
FKGK18 is a selective inhibitor of group VIA calcium-independent phospholipase A2 (GVIA iPLA2), specifically targeting iPLA2β and iPLA2γ with IC50 values of 50 nM and 3 μM respectively. This fluoroketone-based compound is instrumental in studying mechanisms of beta-cell apoptosis and the pathology of diabetes. Its role in modulating phospholipid metabolism makes it a valuable tool for researchers investigating related metabolic disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 1071001-09-6 |
| Applications | GVIA iPLA2 Inhibitor |
| Formula | C16H15F3O |
| Molecular Weight | 280.28 |
| SMILES | O=C(CCCCC1=CC=C2C=CC=CC2=C1)C(F)(F)F |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.