FL77-24 is an analog of FL118 that functions as an apoptosis inducer, demonstrating potent antitumor activity across various cancer cell lines. It exhibits IC50 values of 99.4 nM in HCT116, 118 nM in HepG2, <6.4 nM in MCF-7, 28.5 nM in A549, and <6.4 nM in HeLa cells. FL77-24 primarily induces cell cycle arrest in the S and G2/M phases, making it a valuable reagent for cancer research applications focused on therapeutic development and mechanistic studies of apoptosis.
Fig. 1 · Structure
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FL77-24
Anticancer Agent
FL77-24 is an analog of FL118 that functions as an apoptosis inducer, demonstrating potent antitumor activity across various cancer cell lines. It exhibits IC50 values of 99.4 nM in HCT116, 118 nM in HepG2, <6.4 nM in MCF-7, 28.5 nM in A549, and <6.4 nM in HeLa cells. FL77-24 primarily induces cell cycle arrest in the S and G2/M phases, making it a valuable reagent for cancer research applications focused on therapeutic development and mechanistic studies of apoptosis.
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Biological Activity
Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inducer |
| CAS Number | 2413582-39-3 |
| Applications | Anticancer Agent |
| Formula | C29H24N2O8 |
| Molecular Weight | 528.51 |
| Synonyms | 7-(4-Ethylphenyl)-FL118 |
| SMILES | CC[C@]1(C(OCC2=C1C=C3C4=NC5=C(C(C6=CC(OC)=CC(OC)=C6)=C4CN3C2=O)C=C7OCOC7=C5)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.