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Fmoc-L-Lys(N3-Aca-DIM)-OH

Azide Compound

Fmoc-L-Lys(N3-Aca-DIM)-OH is a click chemistry reagent featuring an azide group, designed for use in solid-phase peptide synthesis (SPPS). This compound serves as a building block for the "helping hand" strategy, enabling the purification of highly insoluble peptides by facilitating the addition of solubilizing residues to lysine side chains via Click-chemistry. The attached solubilizing tag can be cleaved using 1M hydrazine or hydroxylamine solution. Additionally, it is capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) and ring strain-promoted alkyne-azide cycloaddition (SPAAC) with alkyne-containing compounds like DBCO or BCN.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2408993-39-3
Applications	Azide Compound
Formula	C₃₅H₄₃N₅O₆
Molecular Weight	629.75
SMILES	[N-]=[N+]=NCCCCC/C(NCCCC[C@@H](C(O)=O)NC(OCC1C2=CC=CC=C2C3=CC=CC=C31)=O)=C4C(CC(C)(CC/4=O)C)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.