Fig. 1 · Structure

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Fmoc-Val-Cit-PAB-Exatecan

Anticancer Agent

Fmoc-Val-Cit-PAB-Exatecan is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It comprises the ADC linker Fmoc-Val-Cit-PAB and the potent DNA topoisomerase I inhibitor Exatecan, which facilitates targeted delivery and enhanced cytotoxicity in cancer cells. This compound is valuable in the development of targeted cancer therapeutics, enabling researchers to explore pathways of tumor cell resistance and improve efficacy in cancer treatment.

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Specifications

Manufacturer Adooq Bioscience
CAS Number 2754384-69-3
Applications Anticancer Agent
Formula C58H59FN8O11
Molecular Weight 1063.13
SMILES
FC(C=C(N=C1C2=CC3=C4COC([C@](CC)3O)=O)C5=C6CC[C@H](NC(OCC7=CC=C(NC([C@@H](NC([C@@H](NC(OCC8C9=CC=CC=C9C%10=CC=CC=C%108)=O)C(C)C)=O)CCCNC(N)=O)=O)C=C7)=O)C5=C1CN2C4=O)=C6C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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