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Fmoc-Val-Lys-PAB-Exatecan

Exatecan Derivative

Fmoc-Val-Lys-PAB-Exatecan is a derivative of Exatecan, designed primarily for the development of antibody-drug conjugates (ADCs). This compound can be conjugated to monoclonal antibodies through linkers, facilitating targeted delivery of cytotoxic agents to cancer cells. It is particularly utilized in research focused on tumors that exhibit elevated expression of CD70, enhancing the therapeutic potential of ADCs in oncological applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2901788-27-8
Applications	Exatecan Derivative
Formula	C₅₈H₆₀FN₇O₁₀
Molecular Weight	1034.14
SMILES	O=C(OCC1C2=CC=CC=C2C3=CC=CC=C31)N[C@@H](C(C)C)C(N[C@@H](CCCCN)C(NC(C=C4)=CC=C4COC(N[C@@H]5C6=C7C(C(N8C7)=CC([C@](O)(C(OC9)=O)CC)=C9C8=O)=NC%10=CC(F)=C(C)C(CC5)=C%106)=O)=O)=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.