Fig. 1 · Structure
Documents & Downloads
Fmoc-VAP-MMAE
Drug-Linker Conjugates
Fmoc-VAP-MMAE is a drug-linker conjugate designed for antibody-drug conjugate (ADC) applications. It features a potent tubulin inhibitor, MMAE, covalently linked via a proprietary ADC linker and includes a protective Fmoc group. This compound plays a crucial role in targeted cancer therapy by enabling selective delivery of cytotoxic agents to tumor cells, thereby enhancing therapeutic efficacy while minimizing systemic toxicity.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1912408-91-3 |
| Applications | Drug-Linker Conjugates |
| Formula | C70H98N8O13 |
| Molecular Weight | 1259.57 |
| SMILES | O=C(N1[C@](CCC1)([H])[C@H](OC)[C@@H](C)C(N[C@H](C)[C@H](C2=CC=CC=C2)O)=O)C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(OCC(C=C3)=CC=C3NC([C@H](C)NC([C@H](C(C)C)NC(OCC4C5=CC=CC=C5C6=CC=CC=C64)=O)=O)=O)=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.