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FN-1501

Name: FN-1501
Brand: Adooq Bioscience
SKU: A13559
Availability: InStock

Cat. No. A13559 CAS 1429515-59-2

FLT3/CDK inhibitor

FN-1501 is a potent inhibitor of FLT3 and CDK, with IC50s of 2.47, 0.85, 1.96, and 0.28 nM for CDK2/cyclin A, CDK4/cyclin D1, CDK6/cyclin D1 and FLT3, respectively. FN-1501 has anticancer activity.

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Biological Activity

Target & Activity

Target	Activity	Value
Cdk4/cyclin D1	IC50	0.85 nM
CDK6/cyclinD1	IC50	1.96 nM
cdk2/cyclin A	IC50	2.47 nM
FLT3	IC50	0.28 nM

Cellular Effect

Cell Line	Activity	Value	Description	Reference
BaF3	IC50	7.65 nM	Antiproliferative activity against mouse BaF3 cells harboring FLT3-ITD-F691L mutant assessed as reduction in cell viability incubated for 72 hrs by CellTiterGlo luminescent assay	[PMID: 34550682]
HCT-116	GI50	0.09 μM	Growth inhibition of human HCT116 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]
Lymphocyte	IC50	0.492 μM	Cytotoxicity against human lymphocytes assessed as decrease in cell viability after 72 hrs by MTT assay	[PMID: 29357250]
MCF7	GI50	2.84 μM	Growth inhibition of human MCF7 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]
MGC-803	GI50	0.37 μM	Growth inhibition of human MGC803 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]
MV4-11	IC50	0.008 μM	Growth inhibition of human MV4-11 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]
MV4-11	IC50	6.38 nM	Antiproliferative activity against human MV4-11 cells assessed as inhibition of cell growth incubated for 72 hrs by CellTiterGlo luminescent assay	[PMID: 34550682]
NCI-H82	GI50	0.11 μM	Growth inhibition of human NCI-H82 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]
PC-3	IC50	0.69 μM	Antiproliferative activity against AR-negative human PC3 cells assessed as reduction in cell viability after 5 days by CCK8 assay	[PMID: 31846828]
RS4-11	GI50	0.05 μM	Growth inhibition of human RS4:11 cells after 72 hrs by CellTiter-Glo assay	[PMID: 29357250]

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Specifications

Manufacturer	Adooq Bioscience
Actions	Inhibitor
CAS Number	1429515-59-2
Applications	FLT3/CDK inhibitor
Formula	C₂₂H₂₅N₉O
Molecular Weight	431.49
SMILES	O=C(C1=NNC=C1NC2=NC=NC3=C2C=CN3)NC4=CC=C(CN5CCN(C)CC5)C=C4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.