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FNIII14

Catalog No.: A57466
Anti-adhesive Peptide
FNIII14 is an anti-adhesive peptide derived from the 14th fibronectin type III repeat. It effectively inhibits cell adhesion to the extracellular matrix by inducing a conformational change in β1-integrin, shifting it from an active to an inactive state and blocking integrin-mediated signaling. FNIII14 demonstrates anti-fibrotic and anti-cancer properties, making it a valuable tool for research in areas such as metabolic diseases, organ fibrosis, and malignant tumors.
FNIII14 206536-96-1 Anti-adhesive Peptide
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionFNIII14 is an anti-adhesive peptide derived from the 14th fibronectin type III repeat. It effectively inhibits cell adhesion to the extracellular matrix by inducing a conformational change in β1-integrin, shifting it from an active to an inactive state and blocking integrin-mediated signaling. FNIII14 demonstrates anti-fibrotic and anti-cancer properties, making it a valuable tool for research in areas such as metabolic diseases, organ fibrosis, and malignant tumors.
Product Information
Catalog NumA57466
FormulaC103H163N21O35
Molecular Weight2255.52
CAS Number206536-96-1
SequenceThr-Glu-Ala-Thr-Ile-Thr-Gly-Leu-Glu-Pro-Gly-Thr-Glu-Tyr-Thr-Ile-Tyr-Val-Ile-Ala-Leu
Sequence shorteningTEATITGLEPGTEYTIYVIAL
SMILESC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H]([C@@H](C)O)N)=O)CCC(O)=O)=O)C)=O)[C@@H](C)O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)=O)CC(C)C)=O)CCC(O)=O)(=O)N1[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC2=CC=C(O)C=C2)C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC(C)C)C(O)=O)=O)C)=O)[C@H](CC)C)=O)C(C)C)=O)=O)[C@H](CC)C)=O)[C@@H](C)O)=O)=O)CCC(O)=O)=O)[C@@H](C)O)=O)=O)CCC1
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