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Fonsartan free acid

AT1R Antagonist

Fonsartan free acid is a potent angiotensin II receptor (AT1R) antagonist with an IC50 value of 0.48 nM, demonstrating significant antihypertensive properties. It effectively dose-dependently inhibits angiotensin II-induced pressor responses in animal models, with an ID50 of 0.11 mg/kg. Fonsartan free acid is primarily utilized in research focused on hypertension and related cardiovascular disorders.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Antagonist
CAS Number	144628-52-4
Applications	AT1R Antagonist
Formula	C₂₆H₃₂N₄O₅S₂
Molecular Weight	544.69
Synonyms	HOE-720 free acid
SMILES	O=C(C1=C(SC)N=C(CCCC)N1CC2=CC=C(C3=C(S(=O)(NC(NCCC)=O)=O)C=CC=C3)C=C2)O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.