Foxy-5 is a WNT5A agonist that functions as a mimetic peptide of the WNT5A protein, a key player in non-canonical Wnt signaling pathways. It induces cytosolic free calcium signaling while leaving β-catenin activation unaffected, and has been shown to inhibit the migration and invasion of epithelial cancer cells. Additionally, Foxy-5 effectively reduces metastatic spread in WNT5A-low prostate cancer cells within an orthotopic mouse model, making it a valuable reagent for cancer research and therapeutic investigations.
Foxy-5 is a WNT5A agonist that functions as a mimetic peptide of the WNT5A protein, a key player in non-canonical Wnt signaling pathways. It induces cytosolic free calcium signaling while leaving β-catenin activation unaffected, and has been shown to inhibit the migration and invasion of epithelial cancer cells. Additionally, Foxy-5 effectively reduces metastatic spread in WNT5A-low prostate cancer cells within an orthotopic mouse model, making it a valuable reagent for cancer research and therapeutic investigations.
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