Fig. 1 · Structure
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FPT
5-HT1A/5-HT1B/5-HT1D Agonist
FPT is a 2-aminotetralin that acts primarily as a partial agonist at the 5-HT1A receptor, and as a full agonist at both 5-HT1B and 5-HT1D receptors, exhibiting EC50 values of 39.3 nM, 1.2 nM, and 0.5 nM, respectively. Additionally, FPT displays weak agonistic activity at the 5-HT7 receptor. This compound demonstrates in vivo efficacy as an antiepileptic agent in Fmr1 knockout mice and produces anxiolytic-like and prosocial behaviors in various mouse models, making it a valuable tool for researching serotonergic modulation and its implications in neurological disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Partial Agonist |
| CAS Number | 2048491-06-9 |
| Applications | 5-HT1A/5-HT1B/5-HT1D Agonist |
| Formula | C18H20FN |
| Molecular Weight | 269.36 |
| SMILES | FC1=C(C=CC=C1)C2=C3C(C[C@H](CC3)N(C)C)=CC=C2 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.