FPT is a 2-aminotetralin that acts primarily as a partial agonist at the 5-HT1A receptor, and as a full agonist at both 5-HT1B and 5-HT1D receptors, exhibiting EC50 values of 39.3 nM, 1.2 nM, and 0.5 nM, respectively. Additionally, FPT displays weak agonistic activity at the 5-HT7 receptor. This compound demonstrates in vivo efficacy as an antiepileptic agent in Fmr1 knockout mice and produces anxiolytic-like and prosocial behaviors in various mouse models, making it a valuable tool for researching serotonergic modulation and its implications in neurological disorders.
FPT is a 2-aminotetralin that acts primarily as a partial agonist at the 5-HT1A receptor, and as a full agonist at both 5-HT1B and 5-HT1D receptors, exhibiting EC50 values of 39.3 nM, 1.2 nM, and 0.5 nM, respectively. Additionally, FPT displays weak agonistic activity at the 5-HT7 receptor. This compound demonstrates in vivo efficacy as an antiepileptic agent in Fmr1 knockout mice and produces anxiolytic-like and prosocial behaviors in various mouse models, making it a valuable tool for researching serotonergic modulation and its implications in neurological disorders.
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