Fig. 1 · Structure
Documents & Downloads
FR-182980
ACAT1 Inhibitor
FR-182980 is a potent orally active inhibitor of acyl-CoA:cholesterol acyltransferase 1 (ACAT1), with an IC50 of 30 nM. This compound exhibits notable hypocholesterolemic activity, making it a valuable tool for the study of atherosclerosis and related lipid metabolism disorders. Researchers can utilize FR-182980 to investigate the role of ACAT1 in cholesterol homeostasis and its potential as a therapeutic target in cardiovascular diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 179054-51-4 |
| Applications | ACAT1 Inhibitor |
| Formula | C29H34FN3O2S2 |
| Molecular Weight | 539.73 |
| SMILES | O=C(NC1=C(SC)C=C(C)N=C1SC)N(C2CCCCCC2)CC3=CC=C(OC4=CC=C(F)C=C4)C=C3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.